International Union of Pharmacology. XV. Subtypes of g-Aminobutyric AcidA Receptors: Classification on the Basis of Subunit Structure and Receptor Function

نویسنده

  • E. A. BARNARD
چکیده

Molecular Neurobiology Unit (E.A.B.), Royal Free Hospital School of Medicine, London, England; Neuroscience Discovery (P.S.), Lilly Research Laboratories, Indianapolis, Indiana; Department of Pharmacology (R.W.O.), U.C.L.A. School of Medicine, Los Angeles, California; Institute of Pharmacology (H.M.), ETH and University of Zurich, Zurich, Switzerland; Department of Biochemical Psychiatry (W.S.), University of Vienna, Vienna, Austria; Department of Experimental Biology (G.B.), University of Cagliari, Cagliari, Italy; Pharmaceutical Division (C.B.), Schering A.G., Berlin, Germany; Department of Pharmacology, University of Alberta (A.N.B.), Edmonton, Canada; Synthélabo Recherche (L.E.R.S.) (S.Z.L.), Bagneux, France

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منابع مشابه

International Union of Pharmacology. LXX. Subtypes of -Aminobutyric AcidA Receptors: Classification on the Basis of Subunit Composition, Pharmacology, and Function. Update

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International Union of Pharmacology. XV. Subtypes of gamma-aminobutyric acidA receptors: classification on the basis of subunit structure and receptor function.

Molecular Neurobiology Unit (E.A.B.), Royal Free Hospital School of Medicine, London, England; Neuroscience Discovery (P.S.), Lilly Research Laboratories, Indianapolis, Indiana; Department of Pharmacology (R.W.O.), U.C.L.A. School of Medicine, Los Angeles, California; Institute of Pharmacology (H.M.), ETH and University of Zurich, Zurich, Switzerland; Department of Biochemical Psychiatry (W.S.)...

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International Union of Pharmacology. LXX. Subtypes of gamma-aminobutyric acid(A) receptors: classification on the basis of subunit composition, pharmacology, and function. Update.

In this review we attempt to summarize experimental evidence on the existence of defined native GABA(A) receptor subtypes and to produce a list of receptors that actually seem to exist according to current knowledge. This will serve to update the most recent classification of GABA(A) receptors (Pharmacol Rev 50:291-313, 1998) approved by the Nomenclature Committee of the International Union of ...

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P145: The Role of γ-Aminobutyric Acid Receptor in The Social Anxiety Disorder

Social anxiety disorder (SAD) is the one of the most common anxiety disorders. Despite its high prevalence, the disorder is still considerably undiagnosed and untreated. The disease places a massive burden on patient’s lives, affecting not only their social interactions but also their educational and professional activities, thereby constituting a severe disability. γ-aminobutyric acid (GABA) s...

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The Role of a1 and a6 Subtype Amino-Terminal Domains in Allosteric Regulation of g-Aminobutyric Acida Receptors

The g-aminobutyric acidA (GABA) receptor in the mammalian central nervous system is composed of pentameric combinations of a1–6, b1–4, g1–3, d1, and/or e1 subunit subtypes. Although each of the different subunits influences the functional properties of g-aminobutyric acidA receptors (GABARs), the a subunit subtypes have been shown to be important for activation of the receptor by GABA and pento...

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تاریخ انتشار 1998